Hopefully 1st of many more to come
Hands sprayed with fluorescent material. Effect of washing time on cleanliness. Show your kids.
"Transplanting senescent cells accelerated most or all of the diseases that mice die of in old age,ā Kirkland tells The Scientist. But he had a plan to impede the decline.
In another experiment, technicians fed 20-month-old miceāroughly the equivalent of 57- to 67- year-old humansāa mixture of two drugs that Kirkland had previously demonstrated could selectively kill senescent cells: dasatinib, a drug often used in conjunction with chemotherapy, and quercetin, a flavonoid found in onions and apples.
Just two weeks after receiving the combo treatment, the mice ran further, performed better on other physical tests, and were 36 percent less likely to die the following year compared with animals that had received injections of senescent cells but no drug cocktail, Kirkland and his colleagues reported in 2018.
Together with other research, these findings fortified the idea that killing off senescent cells can rescue old animals from the physical deterioration that comes with age, and extend the duration of healthy, disease-free life."
Interesting new tool. Homing in on individual mutation processes.
Wash your hands rebel scum, or the dark side you will enter!
Epub Abstract ahead of publication.
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
Lisa E. Gralinski, et.al.
"While the precise mechanism of complement activation following SARS-CoV MA15 infection is still unclear, it is likely through recognition of the viral spike glycoprotein and partially mediated by MBL (see Fig. S1 in the supplemental material).
The anaphylatoxins produced by the activated complement pathway, C4a, C3a, and C5a, have important immunostimulatory roles in vascular permeability and inflammatory cell recruitment (35, 48). C3a and C5a in particular are noted for their roles in causing mast cell degranulation, initiating a cytokine storm, promoting vascular permeability, and contributing to acute lung injury (36, 49, 50).
Furthermore, a C5a antibody blockade was recently shown to protect in a model of highly susceptible MERS-CoV mice (16). Although there are no reports of mast cell activation following SARS-CoV or MERS-CoV infection, activation has been observed both in vitro and in vivo following infection with influenza virus (51) and may occur following other
severe respiratory infections, including coronaviruses.
Mast cells release cytokines, including IL-6, IL-1, and TNF-Ī±, consistent with the inflammatory profile observed following SARS-CoV MA15 infection.
While this work cannot definitively conclude that the complement anaphylatoxins and mast cell activation contribute to SARS-CoV MA15 pathogenesis, the data are consistent with this possibility, and the concept warrants further investigation."
Hereās the real deal on Corona Viruses. More important, starting on page 31 is one of the best index/glossaries with immune system definitions Iāve seen.
1/30/2020 Disease Briefing: Coronaviruses
Mast cells in human airways: the culprit?
Jonas S. Erjefa
The CDC said to avoid catching the flu or corona virus donāt touch your face. Most stores are out of N95 and surgical masks. One of my former students had this idea.
Available at your local pet store in all sizes.
Allergy Doc locator from AAAAI newsletter .
Alas poor Duncan, had he just worn his mask and washed his handsā¦
āA little water clears us of this deedā Act 5 Scene 1
A basic set of books to help you arm up, strap up, and get ready to ride posseā¦
There are several āmass mediaā books before you get to the texts.
Pam Hodgeāsā¦ My Crazy Life with Mast Cell Disorders
Amber Walkerāsā¦Mast Cells United: A Holistic Approach to Mast Cell Activation Syndrome
Dr Larry Afrināsā¦Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
And Iike this paper for a good overview, it gives you the terminology at a moderate level but a good whole.anatomy look. Frontiers | Mast Cell: A Multi-Functional Master Cell
Big market now for a washed my hands detector and a touched your nose detector
Thought this was a real titleā¦
Not. But a good idea. Great blog though. Interesting read on possible links of MCAS and ASD.
Summary of JAMA Paywalled article
Changes in List Prices, Net Prices, and Discounts for Branded Drugs in the US, 2007-2018
Inmaculada Hernandez, PharmD, PhD1,2; Alvaro San-Juan-Rodriguez, PharmD1,2; Chester B. Good, MD, MPH2,3,4,5; et alWalid F. Gellad, MD, MPH2,3,5
Author Affiliations
JAMA. 2020;323(9):854-862. doi:10.1001/jama.2020.1012
Articles
Key Points
Question To what extent have manufacturer discounts offset increases in list prices of branded pharmaceutical products in the US?
Findings Using 2007-2018 net pricing data on branded pharmaceutical products in the US, list prices increased by 159% and net prices increased by 60%.
Discounts increased from 40% in 2007 to 76% in 2018 in Medicaid and increased from 23% to 51% in other payers, offsetting 62% of increases in list prices for drugs.
Meaning Although discounts partially offset list price increases of branded products from 2007 to 2018, there was still a substantial increase in net prices over this period. (96%)
https://jamanetwork.com/journals/jama/article-abstract/2762310
JAMA Summary Article (Article Paywalled)
Although spending on low back and neck pain, other musculoskeletal disorders, and diabetes accounted for the highest amounts of spending, the payers and the rates of change in annual spending growth rates varied considerably.
US Health Care Spending By Payer and Health Condition, 1996 to 2016
From 1996 to 2016, total health care spending increased from an estimated $1.4 trillion to an estimated $3.1 trillion.
In 2016, private insurance accounted for 48.0% (95% CI, 48.0%-48.0%) of health care spending, public insurance for 42.6% (95% CI, 42.5%-42.6%) of health care spending, and out-of-pocket payments for 9.4% (95% CI, 9.4%-9.4%) of health care spending.
After adjusting for population size and aging, the annualized spending growth rate was 2.6% (95% CI, 2.6%-2.6%) for private insurance, 2.9% (95% CI, 2.9%-2.9%) for public insurance, and 1.1% (95% CI, 1.0%-1.1%) for out-of-pocket payments.