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General
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Folks here’s one of two things to watch for. The other is heart complications and I don’t have a bead on it yet. Will post when I can.

  1. Immune system mast cells, etc. ramp up and do their thing and attack the invader.

  2. Too much of a good thing and “something …” triggers hyper production of immune cells in thinking and wham-o… bang-o… .pneumonia like fluid concentrations…

"Scientists have mapped key elements of a severe immune overreaction -— a “cytokine storm” -— that can both sicken and kill patients who are infected with certain strains of flu virus.

A cytokine storm is an overproduction of immune cells and their activating compounds (cytokines), which, in a flu infection, is often associated with a surge of activated immune cells into the lungs.

The resulting lung inflammation and fluid buildup can lead to respiratory distress and can be contaminated by a secondary bacterial pneumonia – often enhancing the mortality in patients."

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Well, the flu diarrhea with no TP is apocalyptic…Wash your hands​:grin::grin::grin::nauseated_face::face_vomiting::pray:

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Double Aught Costco Hand Sanitizer Load will get it Bubba!

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Herea the updated list of disinfectants from CDC against SARS COV-2

The EPA-registered surface disinfectant products on our Disinfectants for Use Against SARS-CoV-2 list have qualified under EPA’s emerging viral pathogen program for use against SARS-CoV-2, a coronavirus that causes COVID-19. Coronaviruses are enveloped viruses, meaning they are one of the easiest types of viruses to kill with the appropriate disinfectant product.

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New experimental non pharmaceutical treatment for cytokine hyper response syndrome. 40,000+ applications in the EU.

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Farr’s Law and COVID-19

COVID-19 May burn itself out naturally by summer.

Farr’s law was formulated by Dr William Farr in 1840 indicates that Epidemic outbreaks follow a bell-curve pattern.

Almost all epidemics follow this pattern, including a sharp increase in cases at the beginning of the cycle, a peak, and then a decline in cases and a return to baseline.

The pattern exists because human beings modify their behavior to avoid getting sick, and those who do get sick seek medical attention.

China, which had its first cases in December, peaked in late January or early February, and now is in the decline of spread phase because of modified behavior (Quarantines, social distancing, medical care, etc).

US is about 45-50 days behind where China sits, still in the ‘up’ phase of the Bell Curve.

Farr’s law indicates that our Peak in cases should be in April/early May, and then a decline through June/July.

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Researchers at the University of North Carolina at Chapel Hill tested conventional household disinfectants, hospital disinfectants and natural alternatives to measure each product’s ability to kill specific hazardous microbes.
Conventional disinfectants used in the experiment included Clorox, ethanol, Mr. Clean Ultra, Lysol Disinfectant Spray and Lysol Antibacterial Kitchen Cleaner. Hospital disinfectants were TBQ, Vesphene and ethanol. Natural alternatives included vinegar and baking soda.
“The good news was that [all of the commercial disinfectants] were very good, eliminating 99.9 percent or more of microbes,” said William Rutala, professor of medicine at UNC. “The bad news was that such natural products as vinegar and baking soda didn’t work nearly as well.”

https://www.cnn.com/2000/NATURE/01/31/disinfectants.enn/index.html

Antimicrobial Activity of Home Disinfectants and Natural Products Against Potential Human Pathogens •
Article (PDF Available) in Infection Control and Hospital Epidemiology 21(1):33-8

https://www.researchgate.net/profile/Mark_Sobsey/publication/12659151_Antimicrobial_Activity_of_Home_Disinfectants_and_Natural_Products_Against_Potential_Human_Pathogens/links/00b7d516c339655921000000/Antimicrobial-Activity-of-Home-Disinfectants-and-Natural-Products-Against-Potential-Human-Pathogens.pdf

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Antimicrobial Activity of Mast Cells: Role and Relevance of Extracellular DNA Traps

Article (PDF Available) in Frontiers in Immunology 7(10)

https://www.researchgate.net/publication/305393604_Antimicrobial_Activity_of_Mast_Cells_Role_and_Relevance_of_Extracellular_DNA_Traps/fulltext/581bbceb08aeccc08aea8697/Antimicrobial-Activity-of-Mast-Cells-Role-and-Relevance-of-Extracellular-DNA-Traps.pdf

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Be excellent to each other. If you comment, be nice, most all of us are ill and have challenges.

If you have something negative to air, PM an admin.

If you block an administrator or editor to hide your comments, you will be deleted.

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Based on the Farr epidemiological model, why are we restricting travel, closing pertinent dish factories…I mean schools… and big gatherings…as Barney Fife would say…“Nip it in the Bud”

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Here is the heart/cardiovascular impact paper I promised. Key point is thst it attacks the ACE-2 receptor which lines the vascular and heart and GI system. Sartan type ACE 2 inhibitors for hypertension use the same receptor.

Based on post mortem data review on case statistics out of China and Japan, Acute respiratory distress syndrome (ARDS) appears in about 20% of patients. (Cytokine and other mediator over response syndrimenthat causes fluid build up and inflammation in the alveoli resulting in respiratory shock and secondary pneumonia).

There are also some concerns that the virus may also affect the heart.

Early results from China indicate that 16.7% of patients developed arrhythmias, 7.2% developed cardiac injury and 8.7% developed shock. These complication rates were much higher for patients needing ICU admission compared to those who were managed on the floor.

https://www.nature.com/articles/s41569-020-0360-5

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The other possible cause of ARDS type symptoms.

Journal of Virology, https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25728

Increasing evidence shows that coronaviruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases.

The infection of SARS‐CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected.

Furthermore, some coronaviruses have been demonstrated able to spread via a synapse‐connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways.

In light of the high similarity between SARS‐CoV and SARS‐CoV2, it is quite likely that the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19.

Awareness of this will have important guiding significance for the prevention and treatment of the SARS‐CoV‐2‐induced respiratory failure.

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New. What is the course. Median time for viral shedding in this study is 20 days with a max of 37.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext

“Median duration of viral shedding was 20·0 days (IQR 17·0–24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days.”

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Discharge criteria for confirmed COVID-19 cases – When is it safe to discharge COVID-19 cases from the hospital or end home isolation?

NOTE: I expect this to change after the Lancet journal paper today.

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Hmmmm But also couldn’t touch it’s face? :thinking:

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Straight and simple, no hype.

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Impact of mast cells in systemic lupus erythematosus: can inflammation be inhibited?

Article (PDF Available) in Journal of biological regulators and homeostatic agents 33(3):669-673 ·

https://www.researchgate.net/profile/Pio_Conti/publication/333802785_Impact_of_mast_cells_in_systemic_lupus_erythematosus_can_inflammation_be_inhibited/links/5d0a11b992851cfcc622cfd1/Impact-of-mast-cells-in-systemic-lupus-erythematosus-can-inflammation-be-inhibited.pdf

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An overview of mast cell pattern recognition receptors

Justyna Agier, Joanna Pastwińska & Ewa Brzezińska-Błaszczyk

"For a long time, mast cells (MCs) have been recognized as the critical immune system weapon in the allergic reactions [1, 2], as well as during parasitic infections [3]. Indeed, these immune system’s chief sentinels hold a multitude of functions in the host defense against a variety of microorganisms, mainly bacteria and viruses.

Particularly, important role in microbial sensing is achieved due to the presence of different pattern recognition receptors (PRRs). The best-described receptors are Toll-like receptors activated by different pathogen- and damage-associated molecular patterns. However, MCs express also C-type lectin receptors specialized in antifungal defense, NOD-like receptors detecting bacterial peptidoglycans, and RIG-like receptors relevant in viral sensing."