One of my favorite procedures 
What happens when you drink 10 oz of Magnesium Citrate? Iâm glad you askedâŠ
12:05 pm: Itâs time. You shotgun a 10 oz bottle like itâs a lukewarm PBR and you donât want to be a pussy in front of your older brotherâs friends.
Itâs suppose to be lemon flavored but itâs becoming quite clear that whoever led the R&D team that day has never actually tasted anything lemon in their life. You are already regretting this decision.
12:06 pm: You deep throat a cupcake like youâve been saving it for the apocalypse because letâs face itâŠthat time is here. Itâs going to turn to liquid form before it even clears your throat but you donât care. All is right in the world at this moment. Hold on to that. Youâre about to enter a very dark period in your life.
12:37 pm: First sign of life. The pressure is growing. You already have 5 lbs of impacted shit in your colon and you basically just drank the âsafe for humansâ version of Drano. You feel a poop coming on finally. You think itâs time. Youâre wrong. You get a little snake of a stool as a teaser.
Take noteâŠthis is the last semi-solid thing you will see leaving your body for the next 24 hours.
12:57 pm: That little science experiment you got cooking is about to reach itâs boiling point. Your stomach is angry now. It hates youâŠyou can feel it. You have exactly .3 seconds to make it to the nearest toilet but you canât run⊠NEVER run! You pray to god there is enough elasticity in your butthole to keep the gates closed 5 more steps as you start to preemptively undo your pants to save valuable time. Almost there. 3âŠ2âŠ1âŠ
12:58 pm: Sweet Mary, mother of GodâŠis this real life? Your cheeks barely hit the seat and all hell breaks loose. The shit/ water mixture youâve just created comes out with such force that it actually sprays the back of the toilet bowl at a 45 degree angle thus deflecting it in every direction but down.
Is that blood?
False alarm.
Thatâs just the remnants of a cherry pie you ate at ThanksgivingâŠwhen you were 5. The smell is horridâŠthe sound is frightening. You try to clench whats left of your asshole to soften the blow but itâs not working. The whole house just heard your liquid shit fart as it gurgled out of your ass.
1:06 pm- 8:30 pm: Everythingâs a blur. You have shit out everything you have ever eaten since the day you were born, everything your ancestors have ever eaten since the early 1800âs, and your asshole now feels like you have a flaming hot Cheeto and the tears of a thousand Jalapeno seeds stuck in it.
Youâre now curled up in the bathtub ugly crying because you have to remain within armâs reach of the toilet at all times. You have the poop sweats.
You meet Jesus.
8:37 pm: Your family will never be able to unsee the things theyâve seen in the last 8 hours.
Youâre broken.
Your assholeâs broken.
Your spiritâs broken.
Life as you know it will never be the same. ButâŠtomorrowâs a new day. Youâre going to wake up, throw on the only remaining pair of underwear you have that doesnât have a shit stain on it, and youâre going to run up to Target with the last shred of dignity you have leftâŠand buy yourself a new toilet brush. Youâve earned it.
Author- Anonymous
ABOVE: © ISTOCK.COM, REMUS86
An outbreak of a new virus known as 2019-nCoV, which began in Wuhan, China, in December, has now sickened more than 900 people and killed at least 26. Efforts to contain the outbreak have caused major disruption in China, particularly in Wuhan and nearby cities, where authorities have stopped most forms of transportation. While researchers quickly identified and sequenced 2019-nCoV, many questions remain about the novel coronavirus, including which species first passed it to humans.
Some great free access info from NEJM.
Scary, appropriate, and ironic that they choose to update this just now.
https://pediatrics.aappublications.org/content/early/2020/01/23/peds.2019-3750
Nikki wants to know: âIs anyone familiar with vogmask or mask that is good to use thank youâ??
Christine wants to know:âIs it safe to get esophagus stretched if you have MCAS? Does anyone know?â??
What is the best treatment for mast cell activation syndrome?
Publish date: September 3, 2019
By Erik Greb
"Physicians can recognize mast cell activation syndrome by learning its associated triggers and symptoms, which affect many organ systems. Patients have good outcomes when they receive the appropriate pharmaceutical and dietary therapies, according to an overview presented at Freston Conference 2019, sponsored by the American Gastroenterological Association.
A blood test for mast cell tryptase and a 24-hour urine test for metabolites of histamine and prostaglandin should be ordered for every patient suspected of having the syndrome.
âIdeally, you do baseline levels of these studies, and then repeat them when patients are symptomatic,â said Dr. Hamilton. âThe tryptase really has to be done within hours of a reaction. That can be a challenge.â
A subset of patients with mast cell activation syndrome have a baseline serum tryptase level greater than 11.4 ng/mL."
What is the best treatment for mast cell activation syndrome?
Publish date: September 3, 2019
By Erik Greb
"Physicians can recognize mast cell activation syndrome by learning its associated triggers and symptoms, which affect many organ systems. Patients have good outcomes when they receive the appropriate pharmaceutical and dietary therapies, according to an overview presented at Freston Conference 2019, sponsored by the American Gastroenterological Association.
A blood test for mast cell tryptase and a 24-hour urine test for metabolites of histamine and prostaglandin should be ordered for every patient suspected of having the syndrome.
âIdeally, you do baseline levels of these studies, and then repeat them when patients are symptomatic,â said Dr. Hamilton. âThe tryptase really has to be done within hours of a reaction. That can be a challenge.â
A subset of patients with mast cell activation syndrome have a baseline serum tryptase level greater than 11.4 ng/mL."
Exciting study as researchers test a virus-like particle that retrains the immune system to tolerate peanuts with a single injection. If it proves out in humans, the platform could potentially be adapted to treat a variety of allergies.
This popped up in my feed. Good talk.
https://www.corebrainjournal.com/npdb-parker/028-lawrence-afrin-mast-cell-activation-syndrome/
Hope for specific food allergies. Single antibody focused vaccine for Peanut Allergy.
https://www.jacionline.org/#http://www.jacionline.org/article/S0091-6749(19)31709-9/fulltext
"We have shown in this study that vaccination against single allergens results in protection against peanut caused by a complex allergen mixture.
Protection was transferrable by IgG antibodies, and the inhibitory receptor FcÎłRIIb present on mast cells and basophils was critical for reduced allergic symptoms. Fig 737 shows a model of the proposed mechanism of action.
In allergic patients, peanut allergens engage IgE molecules on mast cells and basophils, causing their activation and the allergic response (Fig 7, left part). In presence of high levels of IgG antibodies specific for a single allergen, IgG-immune complexes will be formed and bind FcÎłRIIb, causing inhibition of all IgE-mediated signals, including those from IgE molecules cross-linked by other allergens (Fig 7, right part).
This explains why IgG antibodies against single allergens are able to block cellular activation by whole allergen extracts.
These results are in line with previous studies showing that FcÎłRIIb was able to inhibit signals generated by activating receptors that were sensitized with nonâcross-reacting IgE and were not directly coengaged with FcÎłRIIb."
https://www.jacionline.org/#http://www.jacionline.org/article/S0091-6749(19)31709-9/fulltext
From TMS
For our 2020 Rare Disease Day Initiative we are thrilled to announce the launch of a new series of
Patient Voice Forums!
TMS wants to ensure our physicians are aware of the needs and concerns of our mast cell disease community.
Beginning in February we will have a monthly online moderated forum on the various types of Mast Cell Diseases with TMS Advisory Board Physicians.
We hope you will join us for the first
Patient Voice Forum for
Mast Cell Activation Syndrome (MCAS)
Tuesday, February 11, 2020
8:00 pm (Eastern Time)
Featuring Dr. Matthew Hamilton
Please note other physicians will likely be added to the panel
We want to hear from you!
Please submit your questions, comments and thoughts by emailing nurses@tmsforacure.org which will be included in the discussion with Dr. Hamilton.
Please note that only general medical questions/comments can be submitted/addressed about MCAS; physicians cannot give one-on-one advice to patients in this forum.
All submissions must be received by Friday, February 7, 2020.
Additional call-in details will be provided as it nears.
The full schedule for the rest of the Patient Voice series will be published soon!
Thank you so much for your participation in what we know will be a very meaningful event for our entire community.