I think Iâve read this book in the SciFi section
If He wins, He gets corn for LunchâŠIf I win, Heâs Lunch.
Draw 2 Sucker!!
Found on the desktop. Great picture. No clue what paper itâs from. From April 2018
Donât miss our talk about Cytokine Storm Syndrome & COVID-19 with Randy Cron, MD, PhD!
After receiving the email below, we reached to Dr. Cron to invite him to be a guest on DocTalk Live!
Brad,
Hope you are doing well. Always enjoy your DocTalk webcasts. As you know, it appears that a lot of people that die from COVID-19 have experienced âCytokine Storm Syndromeâ (CSS) as part of the disease process. Most of the medications that appear (anecdotally at least) to have some benefit act to suppress the CSS long enough for the patient to improve (hydroxychloroquine, azithromycin, tocilizumab, anakinra, et al).
It just so happens that one of the worldâs great experts is at UAB, Randy Cron, MD, PhD, professor of pediatrics and medicine.
I think it would be great to hear his opinion about whether traditional treatments for CSS that are very effective should be utilized in the hospitalized COVID19 patients to mitigate mortality.
Thanks!
A systematic review of epinephrine degradation with exposure to excessive heat or cold
Hannah G. Parish, et.al.
https://www.annallergy.org/article/S1081-1206(16)30130-2/pdf
A systematic review of epinephrine stability and sterility with storage in a syringe
Hannah G. Parish, et.al.
Drugs Past Their Expiration Date
This article was previously published: The Medical Letter on Drugs and Therapeutics. December 7, 2015;57(1483):164-165.
https://mfprac.com/web2019/07literature/literature/Misc/ExpirationDates_ed.pdf
Just because it made me happy!
A common sense look at ACE-2 and possible therapies against COVID19 damage. (validates papers we posted 2 weeks ago).
For those with Autoimmune comorbidities
Hereâs the N95 shortage issue for medical professionals. Unless your working with the infected, use the alternative.
Why an arbitrary crackdown on 3M mask exports is not well advised. This is why supply chain and domestic sourcing is the KEY to National Security.
#supplychainiskeytonationalsecurity
#globalistssoldusdownthwriver
#hangthemmbaleveragedbuyoutassholes
We need 300 Million per month at current time (March) and can only domestically make 50 million per month, all sources.
[Redirect Notice]
Majority of all masks are made in China.
China is willing to start exporting after their peak is now past. Export and scammer issues aside, Donât want them to cut us off to meet Canada, Europe needs.
âChina has undertaken a mobilization of wartime proportions to expand its output of disposable surgical masks. Daily production soared from about 10 million at the start of February to 115 million at the end of the month, according to the Chinese government.â
#supplychainiskeytonationalsecurity
Not refereed or reviewed. References includedâŠSignup for account to download.
The Wisdom of Treating Covid19 As an Hyperallergenic Response.
Mast Cell and Cytokine Storm Related Morbidity - Perspective, Review and Hypothesis.
SSRN Electronic Library
Not reviewed or refereed, references are included.
Possible Relationship of Mast Cell Degranulationand Cytokine Storm related COVID19 Morbidity inYoung and Old Population â C. Rangwani
"Background
There is a clear link between Influenza A Virus and mast cell degranulation, causing system wide vasodilation.
Mast cells can be directly activated in response to IAV, releasing mediators such histamine, proteases, inflammatory cytokines, and antiviral chemokines, etc, which participate in the excessive inflammatory and pathological response observed during IAV infections.
This is implicated in IAV related pneumonia, exacerbated by non-alveolar macrophages moving to the sites of infection in the alveolar spaces. "
https://www.mdlinx.com/allergy-immunology/article/6690/
Virus may be spread through normal breathing
A letter from the chair of a committee with the National Academy of Sciences said that results of current research are consistent with aerosolization of the virus through normal breathing, in addition to coughing or sneezing.
Harvey Fineberg, MD, wrote the letter in response to a query from the White House Office of Science and Technology Policy.
The letter explained that research at a hospital in China revealed the virus could be suspended in the air as healthcare professionals remove protective gear, while floors are cleaned, or through movements of hospital staff. In addition, research from the University of Nebraska found that the virus could be detected in rooms more than 6 feet from a patient with COVID-19.
SARS-CoV-2 is not as infectious as measles or tuberculosis, but Dr. Fineberg suggested that aerosolized viral droplets may hang in the air, with the potential of infecting passersby. Variables for this scenario include how much viral shedding is present in a particular person and the amount of circulation in the room. A breeze will likely disperse the droplets outdoors.
Dr. Fineberg added that he is likely to begin wearing a non-surgical mask when he goes out in public.
National Academy of Science Letter:
Reposting
Transmission Potential of SARS-CoV-2 in Viral Shedding Observed at the University of Nebraska Medical Center
âDisease spread through both direct (droplet and person-to-person) as well as indirect contact (contaminated objects and airborne transmission) are indicated, supporting the use of airborne isolation precautions.â
"Although this study did not employ any size-fractionation techniques in order to determine the size range of SARS-CoV-2 droplets and particles, the data is suggestive that viral aerosol particles are produced by individuals that have the COVID-19 disease, even in the absence of cough.
First, in the few instances where the distance between individuals in isolation and air sampling could be confidently maintained at greater than 6 ft, 2 of the 3 air samples were positive for viral RNA. Second, 66.7% of hallway air samples indicate that virus-containing particles were being transported from the rooms to the hallway during sampling activities. It is likely that the positive air samples in the hallway were cause by viral aerosol particles transported by personnel exiting the room (16,17). Finally, personal air samplers worn by sampling personnel were all positive for SARS-CoV-2, despite the absence of cough by most patients while sampling personnel were present.
Recent literature investigating human expired aerosol indicates that a significant fraction of human expired aerosol is less than 10 ”m in diameter across all types of activity (e.g. breathing, talking, and coughing; 18) and that upper respiratory illness increases production of aerosol particles (less than 10 ”m; 19). Taken together these results suggest that virus expelled from infected individuals, including from those who are only mildly ill, may be transported by aerosol processes in their local environment, potentially even in the absence of cough or aerosol generating procedures.
Further, a recent study of SARS-CoV-2 in aerosol and deposited on surfaces, indicates infectious aerosol may persist for several hours and on surfaces for as long as 2 days (20).
Despite wide-spread environmental and limited SARS-CoV-2 aerosol contamination associated with hospitalized and mildly ill individuals, effective implementation of airborne isolation precautions including N95 filtering facepiece respirators and powered air purifying respirator use adequately protected health care workers, in the NQU and NBU facilities, preventing health care worker infections.
Health care workers were closely monitored and screened for COVID-19 suggesting the value in implementing IPC protocols that maintain airborne isolation standards including respiratory protection and include routine systematic environmental cleaning and disinfection of patient care areas and surrounding environments."
"The NEJM study also showed that the stability of SARS-CoV-2 to survive on surfaces and in aerosolized form mirrors the stability of the SARS coronavirus (SARS-CoV) that caused the severe acute respiratory syndrome (SARS) outbreak of 2003.
This is critically important information for clinical laboratory professionals in open-space laboratories, phlebotomists collecting medical laboratory specimens, and frontline healthcare workers who come in direct contact with potentially infected patients. They should be aware of every potential COVID-19 transmission pathway.
Hospital infection control teams will be particularly interested in the possibility of airborne transmission, as they often visit infected patients and are tasked with tracking both the source of the infection as well as individuals who may be exposed to sick patients.
The NEJM study, titled âAerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1â was conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), an agency of the US Department of Health and Human Services (HHS), the Centers for Disease Control and Prevention (CDC), Princeton University, and University of California, Los Angeles.
"We found that the stability of SARS-CoV-2 was similar to that of SARS-CoV-1 under the experimental circumstances tested. This indicates that differences in the epidemiologic characteristics of these viruses probably arise from other factors, including high viral loads in the upper respiratory tract and the potential for persons infected with SARS-CoV-2 to shed and transmit the virus while asymptomatic.3,4
Our results indicate that aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus can remain viable and infectious in aerosols for hours and on surfaces up to days (depending on the inoculum shed).
These findings echo those with SARS-CoV-1, in which these forms of transmission were associated with nosocomial spread and super-spreading events,5 and they provide information for pandemic mitigation efforts"
The researchers concluded that SARS-CoV-2 remains in the air âup to three hours post aerosolization.â"
NEJM Paper:
More evidence indicates healthy people can spread virus (Update)
The newest research was published online by the CDC. It focused on 243 cases of coronavirus reported in Singapore from mid-January through mid-March, including 157 infections among people who had not traveled recently.
Scientists found that so-called pre-symptomatic people triggered infections in seven different clusters of disease, accounting for about 6% of the locally acquired cases.
One of those infections was particularly striking. A 52-year-old womanâs infection was linked to her sitting in a seat at a church that had been occupied earlier in the day by two tourists who showed no symptoms but later fell ill, investigators said after they reviewed closed-circuit camera recordings of church services.
