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Published: 27 March 2019
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Friend Cathy found this on Fibromyalgia
Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role?
Review article
Conti P, et al.
"It has been observed that acute stress causes the activation of TH1 cells, while TH2 cells regulate and act on chronic inflammation.
Fibromyalgia (FM) is a chronic, idiopathic disorder which affects about twelve million people in the United States. FM is characterized by chronic widespread pain, fatigue, aching, joint stiffness, depression, cognitive dysfunction and non-restorative sleep. The mechanism of induction of muscle pain and inflammation is not yet clear.
In FM there is an increase in reactivity of central neurons with increased sensitivity localized mainly in the CNS. Mast cells are involved in FM by releasing proinflammatory cytokines, chemokines, chemical mediators, and PGD2. TNF is a cytokine generated by MCs and its level is higher in FM.
The inhibition of pro-inflammatory IL-1 family members and TNF by IL-37 in FM could have a therapeutic effect.
Here, we report for the first time the relationship between MCs, inflammatory cytokines and the new anti-inflammatory cytokine IL-37 in FM."
Wash your hands, don’t touch your face.
Wash your hands at least 20 seconds. Avoiding viruses is good sanitation, not Karma, Chameleon.
As she licks her fingers!
Oh My, you mean that Corona viruses really come from bats???
Story about acquired allergy…I really like the mast cell illustration.
Helping calibrate the doctor this morning