Syncope as a manifestation of mast cell activation disorder
http://www.alergialafe.org/descargas/revistas/SYNCOPE%2520IN%2520MCAD-2015.pdf
Syncope as a manifestation of mast cell activation disorder.
C.C. Pearles
Autonomic Dysfunction and POTS: A Practical Guide
Wade Cooper, D.O. University of Michigan Associate Professor
Neuro-immune interactions in allergic diseases: novel targets for therapeutics
Tiphaine Voisin, Amélie Bouvier and Isaac M. Chiu
"Allergic inflammation in the skin, respiratory tract and the GI tract involves a complex cross-talk between neurons and immune cells that could play a critical role in mediating disease progression. Recent research into these neuro-immune interactions has brought new insights into mechanisms of action in allergic inflammation that go beyond classical roles for both the immune system and the nervous system.
The immune system directly triggers sensory neuron activation through inflammatory mediators such as cytokines, histamine or neurotrophins. This immune-neuron communication mediates key physiological outcomes such as itch in AD, and cough and bronchoconstriction in asthma.
Conversely, neurons directly communicate with immune cells through neurotransmitters including Ach and NA, or neuropeptides including CGRP, SP or VIP to directly modulate the development of type 2 inflammation. Although immune-targeted treatments for allergic diseases have made important recent advances, patients with severe forms of asthma are often resistant to these treatments (166).
Chronic itch and inflammation in AD is also often resistant to treatment (167). The nervous system could thus be a novel and exciting target for these conditions.
Much work remains to discover the tissue-specific cellular and molecular neuroimmune mechanisms involved in allergies and the recent evidence gives hope of finding novel therapeutic targets in this new area of research."
Supramolecular Attraction pulls the wee beasties apart.
https://www.google.com/amp/s/www.marketwatch.com/amp/story/guid/5E0F606C-613C-11EA-BDAC-86A14558BB22
2 yr old hear, 12 yr old in Atlanta
Tell me you didn’t say the whole rhyme!!!
I believe cloth masks with a filter pocket and/or nonwoven fabric filter layer do a better
And a towel, always know know where your towel is.
Inhibitory effects of quail egg on mast cells degranulation by suppressing PAR2-mediated MAPK and NF-kB activation
Priscilia Lianto
Fredrick O. Ogutu
Yani Zhang
Feng He
Huilian Che
DOI: 10.29219/fnr.v62.1084
“In this current study, we investigated the suppressive role of QE in mast cell degranulation and cytokine production of the effect phase response.”
"The researchers monitored the viral shedding of nine people infected with the virus. In addition to tests looking for fragments of the virus’s RNA, they also tried to grow viruses from sputum, blood, urine, and stool samples taken from the patients.
The latter type of testing — trying to grow viruses — is critical in the quest to determine how people infect one another and how long an infected person poses a risk to others.
Importantly, the scientists could not grow viruses from throat swabs or sputum specimens after day 8 of illness from people who had mild infections.
“Based on the present findings, early discharge with ensuing home isolation could be chosen for patients who are beyond day 10 of symptoms with less than 100,000 viral RNA copies per ml of sputum,” the authors said, suggesting that at that point “there is little residual risk of infectivity, based on cell culture.”
The researchers found very high levels of virus emitted from the throat of patients from the earliest point in their illness —when people are generally still going about their daily routines.
Viral shedding dropped after day 5 in all but two of the patients, who had more serious illness. The two, who developed early signs of pneumonia, continued to shed high levels of virus from the throat until about day 10 or 11.
This pattern of virus shedding is a marked departure from what was seen with the SARS coronavirus, which ignited an outbreak in 2002-2003. With that disease, peak shedding of virus occurred later, when the virus had moved into the deep lungs.
Shedding from the upper airways early in infection makes for a virus that is much harder to contain.
The scientists said at peak shedding, people with Covid-19 are emitting more than 1,000 times more virus than was emitted during peak shedding of SARS infection, a fact that likely explains the rapid spread of the virus. "
Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice
Cynthia Kanagaratham, PhD1,2, Yasmeen S. El Ansari, MMSc, et.al.
https://www.jacionline.org/article/S0091-6749(20)30342-0/pdf
At Johns Hopkins, physicians had been scanning scientific papers for clues to potential therapies and the use of protective equipment, said infectious disease physician Annie Antar, whose usual focus is HIV: “But our faculty had a lot of questions, so I thought, physicians in China dealt with this successfully.”
Thousands of health care workers in China have become infected, though most of those cases occurred before stringent PPE practices kicked in. None of the Zhejiang contingent was infected.
As a result of the meeting, Hopkins’ infectious disease staff asked administrators to develop a plan, now, to set up, manage, and staff isolation units, Antar said, “pushing for measures that closely match what was done in China.”
While the Hopkins team is designing an evidence-based response, their Zhejiang colleagues ended the meeting Thursday by praying for the Americans.
FROM 2007 SARS Post Mortem Review, CDC Hello McFly, anybody home, prepared?!!??
““The presence of a large reservoir of SARS-CoV-like viruses in horseshoe bats, together with the culture of eating exotic mammals in southern China, is a time bomb. The possibility of the reemergence of SARS and other novel viruses from animals or laboratories and therefore the need for preparedness should not be ignored.””
Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection
Vincent C C Cheng, Susanna K P Lau, Patrick C Y Woo, Kwok Yung Yuen
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China.
PMID: 17934078 PMCID: PMC2176051 DOI: 10.1128/CMR.00023-07
SHOULD WE BE READY FOR THE REEMERGENCE OF SARS?
"The medical and scientific community demonstrated marvelous efforts in the understanding and control of SARS within a short time, as evident by over 4,000 publications available online.
Despite these achievements, gaps still exist in terms of the molecular basis of the physical stability and transmissibility of this virus, the molecular and immunological basis of disease pathogenesis in humans, screening tests for early or cryptic SARS cases, foolproof infection control procedures for patient care, effective antivirals or antiviral combinations, the usefulness of immunomodulatory agents for late presenters, an effective vaccine with no immune enhancement, and the immediate animal host that transmitted the virus to caged civets in the market at the beginning of the epidemic.
Coronaviruses are well known to undergo genetic recombination (375), which may lead to new genotypes and outbreaks. The presence of a large reservoir of SARS-CoV-like viruses in horseshoe bats, together with the culture of eating exotic mammals in southern China, is a time bomb.
The possibility of the reemergence of SARS and other novel viruses from animals or laboratories and therefore the need for preparedness should not be ignored."
Actual Preprint Paper reference in STAT article below.
"The researchers monitored the viral shedding of nine people infected with the virus. In addition to tests looking for fragments of the virus’s RNA, they also tried to grow viruses from sputum, blood, urine, and stool samples taken from the patients.
The latter type of testing — trying to grow viruses — is critical in the quest to determine how people infect one another and how long an infected person poses a risk to others.
Importantly, the scientists could not grow viruses from throat swabs or sputum specimens after day 8 of illness from people who had mild infections.
“Based on the present findings, early discharge with ensuing home isolation could be chosen for patients who are beyond day 10 of symptoms with less than 100,000 viral RNA copies per ml of sputum,” the authors said, suggesting that at that point “there is little residual risk of infectivity, based on cell culture.”
The researchers found very high levels of virus emitted from the throat of patients from the earliest point in their illness —when people are generally still going about their daily routines.
Viral shedding dropped after day 5 in all but two of the patients, who had more serious illness. The two, who developed early signs of pneumonia, continued to shed high levels of virus from the throat until about day 10 or 11.
This pattern of virus shedding is a marked departure from what was seen with the SARS coronavirus, which ignited an outbreak in 2002-2003. With that disease, peak shedding of virus occurred later, when the virus had moved into the deep lungs.
Shedding from the upper airways early in infection makes for a virus that is much harder to contain.
The scientists said at peak shedding, people with Covid-19 are emitting more than 1,000 times more virus than was emitted during peak shedding of SARS infection, a fact that likely explains the rapid spread of the virus. "
vilo://www.medrxiv.org/content/10.1101/2020.03.05.20030502v1.full.pdf+html